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Anti-human CD28 mAb

Cat. No. M10603

All AbMole products are for research use only, cannot be used for human consumption.

Anti-human CD28 mAb Structure
Size Price Availability Quantity
500ug USD 245  USD245 In stock
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Quality Control & Documentation
  • Purity: >98%, Endotoxin<0.1EU/μg
  • COA
  • MSDS
Biological Activity

CD28 molecule exists on the surface of most T cells and is considered to be a specific surface molecule of T cells. The responsiveness of T cells to antigens is mainly mediated by the CD3/TCR complex, but it also depends on the cooperation of other molecules on the surface of T cells. T cells can be effectively activated through a variety of ways such as CD3/TCR, CD2 and CD28. Mononuclear cells isolated from peripheral blood, bone marrow or cord blood can be cultured for a certain period of time in the presence of CD3, CD28 monoclonal antibodies and various cytokines to obtain CIK (Cytokine-induced Killer) with tumor cell killing activity cell.


Expression host

Hybridoma cells


Concentration 1mg/mL

Chemical Information
Solubility (25°C) PBS
Storage 2-8°C for 3 months, long-term storage at -20°C or -80°C
References

[1] Shin Foong Ngiow, et al. Cancer Res. Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor

[2] Stephen L Shiao, et al. Transplantation. Immunomodulatory properties of FK734, a humanized anti-CD28 monoclonal antibody with agonistic and antagonistic activities

[3] Stamatis-Nick C Liossis, et al. BioDrugs. Costimulation blockade in the treatment of rheumatic diseases

[4] Philip Tan, et al. J Immunol. "Superhumanized" antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28

[5] R S Lee, et al. J Immunol. Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses

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Keywords: Anti-human CD28 mAb supplier, Cytokines and Growth Factors, inhibitors, activators

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