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Anti-human CD20 mAb

Cat. No. M11387
Anti-human CD20 mAb Structure
Size Price Availability Quantity
500μg USD 450  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin <0.01EU/μg
  • COA
  • MSDS
Biological Activity

Expression host: CHO cells
Purity: > 95 %. Sds-page and HIGH performance liquid chromatography were used for analysis
Endotoxin: < 0.01EU/μg
Storage and stability: stored at 2~8℃, valid for 24 months. In case of separate packaging, store in -20℃ storage period of 6 months, -80℃ storage period of 12 months, avoid repeated freeze-thaw.


Biological activity: CD20 is a specific marker molecule on the surface of B lymphocytes. It is expressed on more than 95% of normal or malignant B lymphocytes and is not expressed in hematopoietic stem cells, progenitor cells, and other normal tissues. It is composed of 297 amino acids and has a molecular weight of 33kD. It belongs to non-glycosylated phosphoprotein from 34 to 36kD. Its antigenic epitope is a ring region composed of 43 amino acids in the third and fourth transmembrane regions. CD20 is an ideal antigen for the treatment of B-lymphocyt-related diseases because it has no obvious internalization and no obvious cell surface shedding after binding with antibody. Since the original normal B cells were not affected by the anti-CD20 monoclonal antibody, the anti-CD20 monoclonal antibody was able to rebuild the B cell population after killing most, if not all, lymphoma cells expressing the CD20 molecule as well as normal B cells. Therefore, anti-CD20 monoclonal antibodies are increasingly used in the treatment of B-cell related diseases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin <0.01EU/μg
Solubility N/A
Storage 2-8℃
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