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Anti-human CD137 mAb

Cat. No. M11388
Anti-human CD137 mAb Structure
Size Price Availability Quantity
100μg USD 550  USD550 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin <0.01EU/μg
  • COA
  • MSDS
Biological Activity

Expression host: HEK-293 cells
Purity: > 95%. Sds-page gel and HIGH performance liquid chromatography were used
Endotoxin: < 0.01EU/μg
Storage and stability: stored at 2~8℃, valid for 24 months. In case of separate packaging, store in -20℃ storage period of 6 months, -80℃ storage period of 12 months, avoid repeated freeze-thaw.

Biological activity: CD137 (also known as 4-1BB) is an inducible cell surface receptor, a member of the tumornecrosis factor receptor (TNFR) superfamily. It is encoded by tumor necrosis factor receptor superfamily member 9 (TNFRSF9) gene. It is widely expressed on the surface of activated T cells, NK cells and other human immune cells. Its ligand is CD137L, also a member of TNFSF, and is an inducible costimulatory receptor expressed on activated CD4+ and CD8+ T cells, NKT, NK cells, DC, macrophages, eosinophils, neutrophils, and mast cells, especially on CD8+ T cells. CD137/CD137L modulates T cell-mediated immune responses by transmitting activation, proliferation, or apoptosis signals between immune cells. Activated signal transduction of CD137 stimulates NK and T cell proliferation and produces antitumor activity, as well as long-lasting memory responses. Activated 4-1BB mab was used to activate 4-1BB, which recruited TNFR-related factors TRAF1 and TRAF2 to form heterotrimers. Signal transduction was enhanced through C-Jun N-terminal kinase (JNK) pathway and extracellular signal-regulated kinase (ERK) pathway. The main transcription factor NF-κB regulates the 4-1BB signal, stimulates T cells and antigen presenting cells to proliferate and secrete cytokines, and improves the level of anti-tumor immune response.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin <0.01EU/μg
Solubility N/A
Storage 2-8℃
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