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Anti-human CD137 mAb

Cat. No. M11388
Anti-human CD137 mAb Structure
Size Price Availability Quantity
100ug USD 550  USD550 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin <0.01EU/μg
  • COA
  • MSDS
Biological Activity

Expression host: HEK-293 cells
Purity: > 95%. Sds-page gel and HIGH performance liquid chromatography were used
Endotoxin: < 0.01EU/μg
Storage and stability: stored at 2~8℃, valid for 24 months. In case of separate packaging, store in -20℃ storage period of 6 months, -80℃ storage period of 12 months, avoid repeated freeze-thaw.

Biological activity: CD137 (also known as 4-1BB) is an inducible cell surface receptor, a member of the tumornecrosis factor receptor (TNFR) superfamily. It is encoded by tumor necrosis factor receptor superfamily member 9 (TNFRSF9) gene. It is widely expressed on the surface of activated T cells, NK cells and other human immune cells. Its ligand is CD137L, also a member of TNFSF, and is an inducible costimulatory receptor expressed on activated CD4+ and CD8+ T cells, NKT, NK cells, DC, macrophages, eosinophils, neutrophils, and mast cells, especially on CD8+ T cells. CD137/CD137L modulates T cell-mediated immune responses by transmitting activation, proliferation, or apoptosis signals between immune cells. Activated signal transduction of CD137 stimulates NK and T cell proliferation and produces antitumor activity, as well as long-lasting memory responses. Activated 4-1BB mab was used to activate 4-1BB, which recruited TNFR-related factors TRAF1 and TRAF2 to form heterotrimers. Signal transduction was enhanced through C-Jun N-terminal kinase (JNK) pathway and extracellular signal-regulated kinase (ERK) pathway. The main transcription factor NF-κB regulates the 4-1BB signal, stimulates T cells and antigen presenting cells to proliferate and secrete cytokines, and improves the level of anti-tumor immune response.

Chemical Information
Solubility (25°C) N/A
Storage 2-8℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Javier Glez-Vaz, et al. J Immunother Cancer. Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies

[2] Siaw-Lin Chan, et al. J Mol Recognit. Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models

[3] Unn Hwa Lee, et al. J Immunother. Humanization of antagonistic anti-human 4-1BB monoclonal antibody using a phage-displayed combinatorial library

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