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Antennapedia Peptide

Cat. No. M21328
Antennapedia Peptide Structure
Size Price Availability Quantity
5mg USD 345  USD345 In stock
10mg USD 545  USD545 In stock
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Quality Control & Documentation
Biological Activity

Antennapedia Peptide is a peptide consisting of 16 amino acid residues derived from the homologous domain of the 60 amino acid sequence of the Drosophila transcription factor Antennapedia, which is also a membrane piercing peptide.Sequence:Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys.

Chemical Information
Molecular Weight 2246.80
Formula C104H168N34O20S
CAS Number 188842-14-0
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sima Kousani, et al. Biotechnol Prog. Antennapedia-derived positively-charged peptide faces multiple problems upon their usage as targeting ligand for liposomal doxorubicin

[2] Edmond Dupont, et al. Methods Mol Biol. Penetratin Story: An Overview

[3] G A Pietersz, et al. Vaccine. A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway

[4] P E Thorn, et al. FEBS Lett. The antennapedia peptide penetratin translocates across lipid bilayers - the first direct observation

[5] A Joliot, et al. Proc Natl Acad Sci U S A. Antennapedia homeobox peptide regulates neural morphogenesis

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Keywords: Antennapedia Peptide supplier, Peptides, inhibitors, activators


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