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Anakinra

Cat. No. M10139

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Anakinra Structure
Synonym:

Raleukin; AMG-719

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10mg USD 530  USD530 Out of stock
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Quality Control & Documentation
Biological Activity

Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. Anakinra is the first biological agent to block the pro-inflammatory effects. In vivo, combined Etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, ip. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice. Anakinra enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan.

Product Citations
Chemical Information
Molecular Weight 509.56
Formula C20H23N5O7S2
CAS Number 143090-92-0
Storage 2-8°C, do not freeze
References

[1] B Naziruddin, et al. Am J Transplant. Improved outcomes of islet autotransplant after total pancreatectomy by combined blockade of IL-1β and TNFα

[2] M McCall, et al. Am J Transplant. Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice

[3] Ulf Harnack, et al. Anticancer Res. IL-1 receptor antagonist anakinra enhances tumour growth inhibition in mice receiving peptide vaccination and beta-(1-3),(1-6)-D-glucan

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Keywords: Anakinra, Raleukin; AMG-719 supplier, IL Receptor/Related, inhibitors, activators

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