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AMTB hydrochloride is a tRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
| Molecular Weight | 430.99 |
| Formula | C23H26N2O2S.HCl |
| CAS Number | 926023-82-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Buolamwini. Curr Pharm Des. Cell cycle targets in novel anticancer drug discovery.
| Related TRP Channel Products |
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Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. |
| (S)-ABT-102
(S)-ABT-102 is a potent TRPV1 antagonist, with an IC50 of 123 nM. (S)-ABT-102 can block the activation of TRPV1 by capsaicin. |
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