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Ampicillin

Cat. No. M9210
Ampicillin Structure
Synonym:

Ampicillin acid; Principen; Amcill

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1g USD 119  USD119 In stock
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Quality Control & Documentation
Biological Activity

Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male C57BL/6 mice
Formulation dissolved in normal saline
Dosages 200 mg/kg, daily for 5 days
Administration intraperitoneally [i.p.]
Chemical Information
Molecular Weight 349.40
Formula C16H19N3O4S
CAS Number 69-53-4
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lee KE, et al. Korean J Physiol Pharmacol. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia.

[2] Chopra SL, et al. Can J Comp Med Vet Sci. Effect of Ampicillin on E. Coli of Swine Origin.

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Keywords: Ampicillin, Ampicillin acid; Principen; Amcill supplier, Antibiotic, inhibitors, activators


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