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Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
| Molecular Weight | 645.31 |
| Formula | C25H29I2NO3 |
| CAS Number | 1951-25-3 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Eric T Feduska, et al. J Cardiothorac Vasc Anesth. Acute Amiodarone Pulmonary Toxicity
[3] J W Mason. N Engl J Med. Amiodarone
[4] W C Smith, et al. J La State Med Soc. Amiodarone
[5] M D Freedman, et al. J Clin Pharmacol. Pharmacology and pharmacokinetics of amiodarone
| Related Potassium Channel Products |
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| Palmitoyl-L-carnitine chloride
Palmitoyl-L-carnitine chloride (L-Palmitoylcarnitine chloride) is a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. Palmitoyl-L-carnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. |
| VU0810464
VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165 nM) and GIRK1/4 (EC50=720 nM) channels with improved brain penetration. |
| QO 58
QO 58 is a potent modulator of K(v)7 channels. |
| NS3623
NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. |
| ML67-33
ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. |
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