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Amikacin

Cat. No. M22409
Amikacin Structure
Size Price Availability Quantity
250mg USD 80  USD80 In stock
1g USD 225  USD225 In stock
5g USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

Amikacin is a semi-synthetic kanamycin analog and an aminoglycoside antibiotic with antimicrobial activity against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains.

Chemical Information
Molecular Weight 585.6
Formula C22H43N5O13
CAS Number 37517-28-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hideo Kato, et al. Int J Environ Res Public Health. Amikacin Therapy in Japanese Pediatric Patients: Narrative Review

[2] Maria S Ramirez, et al. Molecules. Amikacin: Uses, Resistance, and Prospects for Inhibition

[3] Abi Jenkins, et al. J Antimicrob Chemother. Amikacin use and therapeutic drug monitoring in adults: do dose regimens and drug exposures affect either outcome or adverse events? A systematic review

[4] No authors listed. Tuberculosis (Edinb). Amikacin

[5] R D Meyer. Ann Intern Med. Amikacin

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