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AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM. AM-1638 exhibits moderate cross-species plasma clearance and volume of distribution, resulting in plasma half-lives suitable for evaluation of its antidiabetic properties in mouse, rat, and cynomologus monkey. AM-1638 exhibits antidiabetic activity in BDF/DIO mice. Moreover, oral administration of full agonist AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%).
| Molecular Weight | 514.63 |
| Formula | C33H35FO4 |
| CAS Number | 1142214-62-7 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, protect from light |
[2] Sanath K Meegalla, et al. Bioorg Med Chem Lett. Discovery of a novel potent GPR40 full agonist
[3] Xiaohui Du, et al. ACS Med Chem Lett. Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists
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