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Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases. It is an analogue of Prostaglandin and is an agonist of Prostaglandin E1.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 354.48 |
| Formula | C20H34O5 |
| CAS Number | 745-65-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 2-8°C, sealed |
[1] Hanchanale V, et al. Expert Opin Pharmacother. Alprostadil for the treatment of impotence.
| Related Prostaglandin Receptor Products |
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| Prostaglandin D2
Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. PGD2 plays a protective role by suppressing inflammation. |
| Tafluprost acid
Tafluprost acid (AFP-172) is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. |
| TG8-260
TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. |
| Camonagrel
Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. |
| BAY 73-1449
BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
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