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Prostaglandin E1 (Alprostadil)

Cat. No. M5401
Prostaglandin E1 (Alprostadil) Structure
Synonym:

Alprostadil; PGE1

Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 135  USD135 In stock
25mg USD 260  USD260 In stock
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Quality Control & Documentation
Biological Activity

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases. It is an analogue of Prostaglandin and is an agonist of Prostaglandin E1.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 354.48
Formula C20H34O5
CAS Number 745-65-3
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hanchanale V, et al. Expert Opin Pharmacother. Alprostadil for the treatment of impotence.

Related Prostaglandin Receptor Products
Carbacyclin

Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.

DT-9081

DT-9081 is a potentially best-in-class, orally active, small molecule prostaglandin EP4 receptor antagonist that reverses prostaglandin E2 (PGE2)-induced immunosuppression in certain tumors by blocking the EP4 receptor present on immune cells.

Unoprostone

Unoprostone is a prostaglandin F2α analog (PGAs) that reduces oxidative stress and light-induced retinal cell death as well as phagocytosis dysfunction by activating BK channels. It can be used in studies related to glaucoma or hypertension.

15-keto-Prostaglandin E2

15-keto-Prostaglandin E2 is an endogenous metabolite.

Prostaglandin B1

Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1.

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Keywords: Prostaglandin E1 (Alprostadil), Alprostadil; PGE1 supplier, Prostaglandin Receptor, inhibitors, activators


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