Alpha-mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
| Molecular Weight | 410.46 |
| Formula | C24H26O6 |
| CAS Number | 6147-11-1 |
| Solubility (25°C) | 37 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Lisna Meylina, et al. Nanoformulations of α-Mangostin for Cancer Drug Delivery System
[2] Tejashri Chavan, et al. The diverse bioactivity of α-mangostin and its therapeutic implications
[3] Nasrul Wathoni, et al. Nanoparticle Drug Delivery Systems for α-Mangostin
[4] Thi Kieu Trang Phan, et al. Alpha-mangostin reduces mechanical stiffness of various cells
[5] Kuo-Jun Zhang, et al. Anticarcinogenic Effects of α-Mangostin: A Review
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