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alpha-D-glucose

Cat. No. M39105
alpha-D-glucose Structure
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Biological Activity

alpha-D-glucose is an endogenous metabolite.

Chemical Information
Molecular Weight 180.16
Formula C6H12O6
CAS Number 492-62-6
Form Solid
Solubility (25°C) Water ≥ 90 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rui Zhang et al. J Immunol. α-d-Glucose-1,6-Biphosphate Induces Dendritic Cell Homing to Enhance the Antitumor Effect of Neoantigen Vaccines

[2] Guodong Weng et al. Sci Rep. α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain

[3] C Rory Goodwin et al. Oncotarget. UDP-α-D-glucose 6-dehydrogenase: a promising target for glioblastoma

[4] Andreas Pföstl et al. Biochem J. Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose

[5] Ewald Pauwels et al. Spectrochim Acta A Mol Biomol Spectrosc. Radiation-induced radicals in alpha-D-glucose: Comparing DFT cluster calculations with magnetic resonance experiments

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Keywords: alpha-D-glucose supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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