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Aloisine A

Cat. No. M30179

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Aloisine A Structure
Synonym:

RP107

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Quality Control & Documentation
Biological Activity

Aloisine A (RP107) is a a potent cyclin-dependent kinase (CDK) inhibitor with IC50s of 0.15 μM, 0.12 μM, 0.4 μM, 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3α (IC50=0.5 μM) and GSK-3β (IC50=1.5 μM). Aloisine A stimulates wild-type CFTR and mutated CFTR, with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research.

Chemical Information
Molecular Weight 267.33
Formula C16H17N3O
CAS Number 496864-16-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Qiong Wu, et al. Mol Inform. Binding Mechanism of Inhibitors to CDK5/p25 Complex: Free Energy Calculation and Ranking Aggregation Analysis

[2] Patricia Rivest, et al. Chem Biol Interact. Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations

[3] Jenny Rowe, et al. Antiviral Res. Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice

[4] Caroline Corbel, et al. Bioorg Med Chem. Identification of potential cellular targets of aloisine A by affinity chromatography

[5] Yvette Mettey, et al. J Med Chem. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

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  Catalog
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Keywords: Aloisine A, RP107 supplier, CDK, inhibitors, activators

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