All AbMole products are for research use only, cannot be used for human consumption.
Alendronate is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. It is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone resorption and induces apoptosis in osteoclasts. It causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). It efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 uM). And it also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
Patent. CN118785884A 2024 Oct 15.
Patent. CN118785884A
Alendronate sodium hydrate purchased from AbMole
Patent. KR20240161812A 2024 Nov 12.
Patent. KR20240161812A
Alendronate sodium hydrate purchased from AbMole
Patent. WO2023170311A1 2023-09-14.
Patent. WO2023170311A1
Alendronate sodium hydrate purchased from AbMole
| Molecular Weight | 326.13 |
| Formula | C4H13NO7P2.3H2O.Na |
| CAS Number | 121268-17-5 |
| Solubility (25°C) | Water 10 mg/mL warmed |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Gennady Ananchenko, et al. Alendronate sodium
[2] W P Olszynski, et al. Alendronate for the treatment of osteoporosis in men
[3] Neil A Reynolds, et al. Alendronate/colecalciferol
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