Free shipping on all orders over $ 500

ALC-0315 (Liquid)

Cat. No. M22500
ALC-0315 (Liquid) Structure


Size Price Availability Quantity
25mg USD 185  USD185 In stock
50mg USD 290  USD290 In stock
100mg USD 460  USD460 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.

Chemical Information
Molecular Weight 766.27
Formula C48H95NO5
CAS Number 2036272-55-4
Solubility (25°C) DMSO 50 mg/mL
Ethanol 80 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Fariba Saadati, et al. Chemistry. A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine

[2] S Moein Moghimi. Mol Ther. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines

[3] Pedro Morais, et al. Front Cell Dev Biol. The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines

[4] Francesca Ferraresso, et al. Mol Pharm. Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells

[5] Jinjin Chen, et al. Proc Natl Acad Sci U S A. Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response

Related Liposome Products

Vaxfectin is a cationic lipid adjuvant for use in the study of plasmid DNA and protein-based vaccines.


98N12-5 is a novel ionizable lipid that can be used in studies related to siRNA delivery.

YSK 05

YSK 05 is a pH-sensitive cationic lipid with good gene silencing and hemolytic activity, overcomes inhibition of endosomal escape by polyethylene glycolization, and improves intracellular transport of non-viral vectors.YSK 05 is effective in enhancing siRNA delivery both in vitro and in vivo.YSK 05 is a pH-sensitive cationic lipid with good gene silencing and hemolytic activity.

1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate

1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid that can be used in the synthesis of phospholipid vesicles to improve protein encapsulation.


AA-T3A-C12 is an anisamide ligand-bolus lipidoid (AA-lipidoid) that can be used to mediate bulk RNA delivery and transfection of activated fibroblasts.

Abmole Inhibitor Catalog

Keywords: ALC-0315 (Liquid), ALC0315 supplier, Liposome, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.