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Alanosine, also known as L-alanosine, is an amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. Alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 149.11 |
| Formula | C3H7N3O4 |
| CAS Number | 5854-93-3 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Menghua Wang, et al. Biosynthesis of the N-N-Bond-Containing Compound l-Alanosine
[4] A K Tyagi, et al. Determinants of the toxicity of L-alanosine to various organs of the mouse
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