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AI-3 is a antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.
| Molecular Weight | 292.8 |
| Formula | C11H13ClO3S2 |
| CAS Number | 882288-28-0 |
| Solubility (25°C) | DMSO 29.28 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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