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Adelmidrol

Cat. No. M20970
Adelmidrol Structure
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Biological Activity

Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.

Chemical Information
Molecular Weight 274.36
Formula C13H26N2O4
CAS Number 1675-66-7
Solubility (25°C) DMSO 55 mg/mL
Water 55 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Francesca Guida, et al. Biomolecules. Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol

[2] Alessandro Del Re, et al. Metabolites. Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent Action

[3] Roberta Fusco, et al. Antioxidants (Basel). Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis

[4] Mahitab Mohamed Nageeb, et al. Naunyn Schmiedebergs Arch Pharmacol. Adelmidrol protects against non-alcoholic steatohepatitis in mice

[5] Daniela Impellizzeri, et al. Biochem Pharmacol. Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation

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