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Adefovir

Cat. No. M8265
Adefovir Structure
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Biological Activity

Adefovir is an antiviral compound that inhibits hepatitis B virus (HBV) DNA polymerase (reverse transcriptase) after intracellular conversion to adefovir diphosphate.

Chemical Information
Molecular Weight 273.19
Formula C8H12N5O4P
CAS Number 106941-25-7
Solubility (25°C) 0.1 M NaOH: ≥5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bahar Darsazan, et al. Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes

[2] Morris Sherman. Why adefovir is not yet available in Canada

[3] David Mutimer. Adefovir-lamivudine combination therapy and hepatitis B viral kinetics

[4] Stephanos J Hadziyannis, et al. Adefovir dipivoxil in the treatment of chronic hepatitis B virus infection

[5] Yi-min Mao, et al. Adefovir dipivoxil-A new drug for hepatitis B

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