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Actarit

Cat. No. M20448
Actarit Structure
Synonym:

4-acetylaminophenylacetic acid

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Biological Activity

Actarit is an orally active immunomodulator used in the treatment of rheumatoid arthritis.

Chemical Information
Molecular Weight 193.20
Formula C10H11NO3
CAS Number 18699-02-0
Solubility (25°C) DMSO 38 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daoyi Guo, et al. Enzyme Microb Technol. Biosynthesis of actarit using engineered Escherichia coli

[2] Ghita Ghislat, et al. Biomolecules. Identification and Validation of Carbonic Anhydrase II as the First Target of the Anti-Inflammatory Drug Actarit

[3] Yuenan Li, et al. Asian J Pharm Sci. Double-layered osmotic pump controlled release tablets of actarit: In vitro and in vivo evaluation

[4] Jiesheng Ye, et al. Int J Pharm. Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis

[5] H Fujisawa, et al. Arzneimittelforschung. Effect of actarit on type II collagen-induced arthritis in mice

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Keywords: Actarit, 4-acetylaminophenylacetic acid supplier, Immunology/Inflammation, inhibitors, activators


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