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Acotiamide dihydrochloride

Cat. No. M9590
Acotiamide dihydrochloride Structure

Z-338 dihydrochloride

Size Price Availability
5mg USD 180  USD200 4-7 Days
10mg USD 351  USD390 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). Acotiamide has activity as a muscarinic antagonist. It acts as a prokinetic compound through acetylcholinesterase inhibition and muscarinic receptor antagonism, and has been used for the treatment of functional dyspepsia (FD) involving gastric motility dysfunction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 487.01
Formula C21H30N4O5S.HCl
CAS Number 185104-11-4
Purity >99%
Solubility Water ≥ 10 mg/mL
Storage at -20°C

Acotiamide Hydrochloride, a Therapeutic Agent for Functional Dyspepsia, Enhances Acetylcholine-induced Contraction via Inhibition of Acetylcholinesterase Activity in Circular Muscle Strips of Guinea Pig Stomach
K Ito, et al. Dτμg Res (Stuttg). 2016 Apr;66(4):196-202. PMID: 26418413.

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Keywords: Acotiamide dihydrochloride, Z-338 dihydrochloride supplier, AChR/AChE, inhibitors

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