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Acolbifene

Cat. No. M45335

All AbMole products are for research use only, cannot be used for human consumption.

Acolbifene Structure
Synonym:

EM-652; SCH 57068

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Quality Control & Documentation
Biological Activity

Acolbifene is an active metabolite of EM800 and an orally active pure anti-estrogen and selective estrogen receptor (ER) antagonist that inhibits estradiol-induced ERα (IC50 = 2 nM) and ERβ (IC50 = 0.4 nM) transcriptional activity and has anticancer activity.

Chemical Information
Molecular Weight 457.56
Formula C29H31NO4
CAS Number 182167-02-8
Form Solid
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Carol J Fabian, et al. Cancer Prev Res (Phila). Clinical Trial of Acolbifene in Premenopausal Women at High Risk for Breast Cancer

[2] Andrea R Genazzani, et al. Expert Opin Emerg Drugs. Emerging hormonal treatments for menopausal symptoms

[3] Mariam H Al-Dhaheri, et al. Steroids. Identification of novel proteins induced by estradiol, 4-hydroxytamoxifen and acolbifene in T47D breast cancer cells

[4] Sylvain Gauthier, et al. J Enzyme Inhib Med Chem. Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution

[5] Ju Liu, et al. Chem Res Toxicol. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides

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Keywords: Acolbifene, EM-652; SCH 57068 supplier, Estrogen Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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