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Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells.
| Molecular Weight | 478.62 |
| Formula | C26H42N2O6 |
| CAS Number | 2082752-83-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 230 mg/mL (ultrasonic) |
| Storage | 4°C, sealed |
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