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Aclimostat

Cat. No. M29178

All AbMole products are for research use only, cannot be used for human consumption.

Aclimostat Structure
Synonym:

ZGN-1061

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Quality Control & Documentation
Biological Activity

Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells.

Chemical Information
Molecular Weight 478.62
Formula C26H42N2O6
CAS Number 2082752-83-6
Form Solid
Solubility (25°C) DMSO 230 mg/mL (ultrasonic)
Storage 4°C, sealed
References

[1] Daniela Grimm, et al. Int J Mol Sci. The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model

[2] Dong Hyun Choi, et al. NPJ Microgravity. 3D cell culture using a clinostat reproduces microgravity-induced skin changes

[3] Krzysztof Wrzesinski, et al. Methods Mol Biol. Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids

[4] Yeong-Min Yoo, et al. Int J Mol Sci. Melatonin Suppresses Autophagy Induced by Clinostat in Preosteoblast MC3T3-E1 Cells

[5] W Briegleb. ASGSB Bull. Some qualitative and quantitative aspects of the fast-rotating clinostat as a research tool

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Keywords: Aclimostat, ZGN-1061 supplier, inhibitors, activators

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