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ABBV-4083 is a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
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Animal models | microfilariae-positive jirds |
Formulation | dissolved in 0.5% HPMC/0.02% Tween-80 |
Dosages | 150 mg/kg QD using a volume of 5ml/kg |
Administration | PO |
Molecular Weight | 1024.21 |
Formula | C53H82FNO17 |
CAS Number | 1809266-03-2 |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Kelly L Johnston, et al. Trends Parasitol. Anti-Wolbachia drugs for filariasis
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