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Aaptamine

Cat. No. M21593
Aaptamine Structure
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100μg USD 520  USD520 1-2 Weeks
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Biological Activity

Aaptamine, an alkaloid isolated from sponge Aaptos aaptos in the ocean, is a competitive antagonist of alpha-adrenergic receptors to activate the p21 promoter independently of the p53 pathway.

Chemical Information
Molecular Weight 228.25
Formula C13H12N2O2
CAS Number 85547-22-4
Solubility (25°C) N/A
Storage 2-8℃, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chun-Sung Sung, et al. Mar Drugs. Antinociceptive Effects of Aaptamine, a Sponge Component, on Peripheral Neuropathy in Rats

[2] Shuang Miao, et al. Pharm Biol. Aaptamine - a dual acetyl - and butyrylcholinesterase inhibitor as potential anti-Alzheimer's disease agent

[3] Vinita Manimaran Nadar, et al. Chem Biol Drug Des. Review on marine sponge alkaloid, aaptamine: A potential antibacterial and anticancer drug

[4] Do Thi Trang, et al. Nat Prod Res. Four new aaptamine alkaloids from marine sponge Aaptos aaptos

[5] Kaikai Gong, et al. Pharm Biol. Aaptamine attenuates the proliferation and progression of non-small cell lung carcinoma

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