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A22 hydrochloride

Cat. No. M8359

All AbMole products are for research use only, cannot be used for human consumption.

A22 hydrochloride Structure

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Quality Control & Documentation
Biological Activity

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

Chemical Information
Molecular Weight 271.59
Formula C8H8Cl2N2S · HCl
CAS Number 22816-60-0
Solubility (25°C) Water: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Anastasia Kotzialampou, et al. Synergistic Antibacterial and Antibiofilm Activity of the MreB Inhibitor A22 Hydrochloride in Combination with Conventional Antibiotics against Pseudomonas aeruginosa and Escherichia coli Clinical Isolates

[2] Fan Zhang, et al. Dietary supplementation with pioglitazone hydrochloride and l-carnosine improves the growth performance, muscle fatty acid profiles and shelf life of yellow-feathered broiler chickens

[3] Li Yang, et al. The anti-inflammatory and antioxidant effects of leonurine hydrochloride after lipopolysaccharide challenge in broiler chicks

[4] Pauline Cordenonsi Bonez, et al. Anti-biofilm activity of A22 ((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: Influence on biofilm formation, motility and bioadhesion

[5] Pauline C Bonez, et al. Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride)

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Keywords: A22 hydrochloride supplier, Antibiotic, inhibitors, activators

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