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A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation.
| Molecular Weight | 527.36 |
| Formula | C25H23Cl2F3N2O3 |
| CAS Number | 2055271-22-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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