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A-740003 is a potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). A-740003 displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. A-740003 reduces nociception in animal models of persistent neuropathic and inflammatory pain. A-740003 also reduces neuroblastoma tumor growth in mice.
| Molecular Weight | 474.55 |
| Formula | C26H30N6O3 |
| CAS Number | 861393-28-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 9.49 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Jie Yin, et al. Role of P2X 7 R in the development and progression of pulmonary hypertension
| Related P2 Receptor Products |
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| BzATP triethylammonium
BzATP triethylammonium salt acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. |
| NF449
NF449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. |
| NF279
NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC50 of 19 nM. |
| NF110
NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). |
| PSB-12062
PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4. |
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