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8-Bromoadenosine

Cat. No. M41560
8-Bromoadenosine Structure
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Biological Activity

8-Bromoadenosine is an adenosine analog.

Chemical Information
Molecular Weight 346.14
Formula C10H12BrN5O4
CAS Number 2946-39-6
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Leo Sala et al. J Phys Chem Lett. Different Mechanisms of DNA Radiosensitization by 8-Bromoadenosine and 2'-Deoxy-2'-fluorocytidine Observed on DNA Origami Nanoframe Supports

[2] Toshinori Suzuki et al. Chem Pharm Bull (Tokyo). Formation of 8-S-L-Cysteinyladenosine from 8-Bromoadenosine and Cysteine

[3] H N Wood et al. Proc Natl Acad Sci U S A. 8-bromoadenosine 3':5'-cyclic monophosphate as a promoter of cell division in excised tobacco pith parenchyma tissue

[4] V Hagen et al. J Photochem Photobiol B. Synthesis, photochemistry and application of (7-methoxycoumarin-4-yl)methyl-caged 8-bromoadenosine cyclic 3',5'-monophosphate and 8-bromoguanosine cyclic 3',5'-monophosphate photolyzed in the nanosecond time region

[5] T G Golos et al. Biochemistry. 8-bromoadenosine cyclic 3',5'-phosphate rapidly increases 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA in human granulosa cells: role of cellular sterol balance in controlling the response to tropic stimulation

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Keywords: 8-Bromoadenosine supplier, Nucleoside Antimetabolite/Analog, inhibitors, activators

 
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