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7-Ethoxy-4-methylcoumarin

Cat. No. M39055
7-Ethoxy-4-methylcoumarin Structure
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Biological Activity

7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6.

Chemical Information
Molecular Weight 204.22
Formula C12H12O3
CAS Number 87-05-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hongli Li et al. Pharmacol Res. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson's disease in mice and Caenorhabditis elegans

[2] Yang Zheng et al. J AOAC Int. Simultaneous Analysis of Simple Coumarins and Furocoumarines in Cigarettes by Solid-Phase Extraction with Gas Chromatography-Mass Spectrometry

[3] Krzysztof Żamojć et al. J Fluoresc. Analysis of fluorescence quenching of coumarin derivatives by 4-hydroxy-TEMPO in aqueous solution

[4] Motoi Ueno et al. J Biosci Bioeng. Enhanced oxidative activities of cytochrome P450Rhf from Rhodococcus sp. expressed using the hyper-inducible expression system

[5] U D Kuhn et al. Exp Toxicol Pathol. Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin

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Keywords: 7-Ethoxy-4-methylcoumarin supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators

 
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