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5HPP-33

Cat. No. M7843

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5HPP-33 Structure

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Quality Control & Documentation
Biological Activity

5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).

Chemical Information
Molecular Weight 323.39
Formula C20H21NO3
CAS Number 105624-86-0
Solubility (25°C) DMSO: ≥20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aijaz Rashid, et al. Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin

[2] Bulbul Pandit, et al. Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action

[3] Nicole Kleinstreuer, et al. A computational model predicting disruption of blood vessel development

[4] Masahiro Kizaki, et al. New tubulin polymerization inhibitor derived from thalidomide: implications for anti-myeloma therapy

[5] Toyotaka Iguchi, et al. Novel tubulin-polymerization inhibitor derived from thalidomide directly induces apoptosis in human multiple myeloma cells: possible anti-myeloma mechanism of thalidomide

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Keywords: 5HPP-33 supplier, inhibitors, activators

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