5'-Deoxy-5'-(Methylthio)adenosine, also known as MTA and Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 3 mg/mL
Water ~1 mg/mL
Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine
Eva Albers. IUBMB Life. 2009 Dec;61(12):1132-42. PMID: 19946895.
Matias A Avila, et al. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. PMID: 15313459.
Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon
F de Ferra, et al. Cancer Res. 1984 Jun;44(6):2297-301. PMID: 6426777.
Salvage of 5'-deoxy-methylthioadenosine into purines and methionine by lymphoid cells and inhibition of cell proliferation
L Christa, et al. Biochim Biophys Acta. 1984 Feb 17;803(1-2):7-10. PMID: 6421333.
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