Free shipping on all orders over $ 500

5'-Deoxy-5'-(Methylthio)adenosine

Cat. No. M10156
5'-Deoxy-5'-(Methylthio)adenosine Structure
Synonym:

MTA; 5'-Methylthioadenosine

Size Price Availability Quantity
50mg USD 98 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

5'-Deoxy-5'-(Methylthio)adenosine, also known as MTA and Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 297.33
Formula C11H15N5O3S
CAS Number 2457-80-9
Purity >99%
Solubility DMSO 3 mg/mL
Water ~1 mg/mL
Storage at -20°C
References

Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine
Eva Albers. IUBMB Life. 2009 Dec;61(12):1132-42. PMID: 19946895.

Methylthioadenosine
Matias A Avila, et al. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. PMID: 15313459.

Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon
F de Ferra, et al. Cancer Res. 1984 Jun;44(6):2297-301. PMID: 6426777.

Salvage of 5'-deoxy-methylthioadenosine into purines and methionine by lymphoid cells and inhibition of cell proliferation
L Christa, et al. Biochim Biophys Acta. 1984 Feb 17;803(1-2):7-10. PMID: 6421333.

Related Endogenous Metabolite Products
D(+)-Xylose

D(+)-Xylose is a natural product, mainly used to produce xylitol, as a non-calorie sweetener in foods and beverages.

H-gamma-Glu-Phe-OH

γ-Glu-Phe (γ-Glutamylphenylalanine) is a γ-3 glutamyl dipeptide synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO).

11C,14C-Eicosadienoic Acid

11C,14C-Eicosadienoic Acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.

L-Lactic acid

L-Lactic acid is an organic acid, which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid.

4-Guanidinobutanoic acid

Gamma-Guanidinobutyric acid (4-GBA) is used to study intestinal transport by the human proton-coupled amino acid transporter(s) (hPAT1).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 5'-Deoxy-5'-(Methylthio)adenosine, MTA; 5'-Methylthioadenosine supplier, Endogenous Metabolite, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.