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Cat. No. M10156
5'-Deoxy-5'-(Methylthio)adenosine Structure

MTA; 5'-Methylthioadenosine

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50mg USD 98 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

5'-Deoxy-5'-(Methylthio)adenosine, also known as MTA and Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 297.33
Formula C11H15N5O3S
CAS Number 2457-80-9
Purity >99%
Solubility DMSO 3 mg/mL
Water ~1 mg/mL
Storage at -20°C

Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine
Eva Albers. IUBMB Life. 2009 Dec;61(12):1132-42. PMID: 19946895.

Matias A Avila, et al. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. PMID: 15313459.

Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon
F de Ferra, et al. Cancer Res. 1984 Jun;44(6):2297-301. PMID: 6426777.

Salvage of 5'-deoxy-methylthioadenosine into purines and methionine by lymphoid cells and inhibition of cell proliferation
L Christa, et al. Biochim Biophys Acta. 1984 Feb 17;803(1-2):7-10. PMID: 6421333.

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Keywords: 5'-Deoxy-5'-(Methylthio)adenosine, MTA; 5'-Methylthioadenosine supplier, Endogenous Metabolite, inhibitors

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