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5'-Deoxy-5'-(Methylthio)adenosine

Cat. No. M10156
5'-Deoxy-5'-(Methylthio)adenosine Structure
Synonym:

MTA; 5'-Methylthioadenosine

Size Price Availability Quantity
25mg USD 48  USD48 In stock
50mg USD 80  USD80 In stock
100mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

5'-Deoxy-5'-(Methylthio)adenosine, also known as MTA and Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.

Chemical Information
Molecular Weight 297.33
Formula C11H15N5O3S
CAS Number 2457-80-9
Solubility (25°C) DMSO 3 mg/mL
Water ~1 mg/mL
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Eva Albers. IUBMB Life. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine

[2] Matias A Avila, et al. Int J Biochem Cell Biol. Methylthioadenosine

[3] F de Ferra, et al. Cancer Res. Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon

[4] L Christa, et al. Biochim Biophys Acta. Salvage of 5'-deoxy-methylthioadenosine into purines and methionine by lymphoid cells and inhibition of cell proliferation

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Keywords: 5'-Deoxy-5'-(Methylthio)adenosine, MTA; 5'-Methylthioadenosine supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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