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5'-Deoxy-5'-(Methylthio)adenosine

Cat. No. M10156
5'-Deoxy-5'-(Methylthio)adenosine Structure
Synonym:

MTA; 5'-Methylthioadenosine

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50mg USD 98  USD98 In stock
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Biological Activity

5'-Deoxy-5'-(Methylthio)adenosine, also known as MTA and Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 297.33
Formula C11H15N5O3S
CAS Number 2457-80-9
Purity 99.94%
Solubility DMSO 3 mg/mL
Water ~1 mg/mL
Storage -20°C, protect from light
References

[1] Eva Albers. IUBMB Life. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine

[2] Matias A Avila, et al. Int J Biochem Cell Biol. Methylthioadenosine

[3] F de Ferra, et al. Cancer Res. Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon

[4] L Christa, et al. Biochim Biophys Acta. Salvage of 5'-deoxy-methylthioadenosine into purines and methionine by lymphoid cells and inhibition of cell proliferation

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Keywords: 5'-Deoxy-5'-(Methylthio)adenosine, MTA; 5'-Methylthioadenosine supplier, Endogenous Metabolite, inhibitors

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