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4-Methylcatechol

Cat. No. M20930
4-Methylcatechol Structure
Synonym:

2-Hydroxy-4-methylphenol; 4-Methyl-1,2-benzenediol (4-methylpyrocatechol); 4-Methyl-1,2-dihydroxybenzene; 4-methyl-2-benzenediol; 4-methyl-benzene-1,2-diol; 4-methyl-pyrocatecho

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Biological Activity

an antagonist of the androgen receptor (AR) signaling pathway

Chemical Information
Molecular Weight 124.14
Formula C7H8O2
CAS Number 452-86-8
Solubility (25°C) DMSO 24 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marcel Hrubša, et al. Nutrients. The Antiplatelet Effect of 4-Methylcatechol in a Real Population Sample and Determination of the Mechanism of Action

[2] Khadija Waqar, et al. Food Chem. Covalent bonding of 4-methylcatechol to β-lactoglobulin results in the release of cysteine-4-methylcatechol adducts after in vitro digestion

[3] Yue Guo, et al. Metabolites. Forming 4-Methylcatechol as the Dominant Bioavailable Metabolite of Intraruminal Rutin Inhibits p-Cresol Production in Dairy Cows

[4] Lenka Applov, et al. Mol Nutr Food Res. 4-Methylcatechol, a Flavonoid Metabolite with Potent Antiplatelet Effects

[5] Chunjin Li, et al. Cell Biol Int. 4-Methylcatechol-induced cell damage in TM4 Sertoli cells

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Keywords: 4-Methylcatechol, 2-Hydroxy-4-methylphenol; 4-Methyl-1,2-benzenediol (4-methylpyrocatechol); 4-Methyl-1,2-dihydroxybenzene; 4-methyl-2-benzenediol; 4-methyl-benzene-1,2-diol; 4-methyl-pyrocatecho supplier, inhibitors, activators

 
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