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4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis.
Molecular Weight | 130.14 |
Formula | C6H10O3 |
CAS Number | 816-66-0 |
Form | Liquid (density 1.055 g/mL) |
Solubility (25°C) | DMSO 90 mg/mL Water 90 mg/mL |
Storage | 2-8°C, protect from light |
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