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4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis.
| Molecular Weight | 130.14 |
| Formula | C6H10O3 |
| CAS Number | 816-66-0 |
| Form | Liquid (density 1.055 g/mL) |
| Solubility (25°C) | DMSO 90 mg/mL Water 90 mg/mL |
| Storage | 2-8°C, protect from light |
| Related Metabolite/Endogenous Metabolite Products |
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| D-Tryptophan
D-Tryptophan is the D-isomer of tryptophan, as a non-protein active amino acid, has special physiological properties, can be used as additives, plant growth agents, etc. In the pharmaceutical industry, it is mainly used in the synthesis of various polypeptides, instead of L-tryptophan to extend the peptide half-life. |
| Arachidonic acid sodium salt
Arachidonic acid sodium salt (Sodium Arachidonate) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). |
| trans-Vaccenic acid
trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. |
| Mead acid
Mead acid (5,8,11-Eicosatrienoic acid) is an unsaturated (Omega-9) fatty acid. |
| p-Cresol glucuronide
p-Cresol glucuronide is a metabolite of p-cresol, it is a prototype protein-bound uremic toxin. |
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