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4-Diethylaminobenzaldehyde

Cat. No. M1516
4-Diethylaminobenzaldehyde Structure
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10g USD 40  USD40 In stock
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Biological Activity

4-Diethylaminobenzaldehyde

Chemical Information
Molecular Weight 177.24
Formula C11H15NO
CAS Number 120-21-8
Solubility (25°C) Soluble in Ethanol
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peng Zhang, et al. In situ generated chromophore as the indicator for background-free sensing strategy of hydrazine with high sensitivity with in vitro and in vivo applications

[2] Bahaar Chawla, et al. Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish

[3] Min Luo, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1

[4] Muzaffer Alkan, et al. Synthesis, acidity and antioxidant properties of some novel 3,4-disubstituted-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives

[5] Naohiro Araki, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells

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Keywords: 4-Diethylaminobenzaldehyde supplier, ALDH, inhibitors, activators

 
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