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4-DAMP

Cat. No. M8269

All AbMole products are for research use only, cannot be used for human consumption.

4-DAMP Structure
Synonym:

4-DAMP methiodide

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Quality Control & Documentation
Biological Activity

4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion.

Chemical Information
Molecular Weight 451.34
Formula C21H26INO2
CAS Number 1952-15-4
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] S W Y Tsang, et al. Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis

[2] F J Ehlert, et al. The use of irreversible ligands to inactivate receptor subtypes: 4-DAMP mustard and muscarinic receptors in smooth muscle

[3] F J Ehlert. The interaction of 4-DAMP mustard with subtypes of the muscarinic receptor

[4] D Collins, et al. Regional binding of 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP) to muscarinic receptors in rat brain and comparative analysis of minimum energy conformations

[5] E A Thomas, et al. Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues

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Keywords: 4-DAMP, 4-DAMP methiodide supplier, AChR/AChE, inhibitors, activators

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