4-CMTB is a potent allosteric agonist of free fatty acid receptor 2 (FFA2).
Molecular Weight | 294.8 |
Formula | C14H15ClN2OS |
CAS Number | 300851-67-6 |
Form | Solid |
Solubility (25°C) | DMSO: ≥10 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Andrew J Brown, et al. Pharmacological properties of acid N-thiazolylamide FFA2 agonists
Related GPR/FFAR Products |
---|
GSK256073
GSK256073 is a potent, selective, orally active GPR109A agonist and a potent and persistent HCA2 agonist with a pEC50 of 7.5 (Human HCA2). In addition, GSK256073 significantly improves glucose homeostasis by inhibiting lipid degradation and has potential for the study of type 2 diabetes mellitus (T2DM) and dyslipidemia. |
GSK4381406
GSK4381406 is a first-in-class, orally active GPR35 agonist for studies related to inflammatory bowel disease (IBD). |
EVO756
EVO756 is a Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist that can be used in studies related to urticaria. |
EP262
EP262 is an orally active small molecule antagonist of the Mas-related G protein-coupled receptor (MRGPRX2) for studies related to mast cell-mediated diseases such as chronic urticaria and atopic dermatitis. |
hMCH-1R antagonist 1
hMCH-1R antagonist 1 is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an KB value of 3.6 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.