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Cat. No. M8281
4-CMTB Structure
Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

4-CMTB is a potent allosteric agonist of free fatty acid receptor 2 (FFA2).

Chemical Information
Molecular Weight 294.8
Formula C14H15ClN2OS
CAS Number 300851-67-6
Form Solid
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Maciej Salaga, et al. Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice

[2] Ju-Hyun Lee, et al. 4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice

[3] Jisoo Kang, et al. FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

[4] John O Adongo, et al. Fabrication and Characterization of Surfaces Modified with Carboxymethylthio Ligands for Chelate-Assisted Trapping of Copper

[5] Andrew J Brown, et al. Pharmacological properties of acid N-thiazolylamide FFA2 agonists

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Keywords: 4-CMTB supplier, GPR/FFAR, inhibitors, activators

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