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(3S,4S)-Tofacitinib

Cat. No. M27778

All AbMole products are for research use only, cannot be used for human consumption.

(3S,4S)-Tofacitinib Structure

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Quality Control & Documentation
Biological Activity

(3S,4S)-Tofacitinib is the less active S-enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

Chemical Information
Molecular Weight 312.37
Formula C16H20N6O
CAS Number 1092578-47-6
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jian-kang Jiang, et al. J Med Chem. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

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  Catalog
Abmole Inhibitor Catalog




Keywords: (3S,4S)-Tofacitinib supplier, JAK, inhibitors, activators

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