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Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside

Cat. No. M40145
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside Structure
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Biological Activity

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid.

Chemical Information
Molecular Weight 824.74
Formula C43H36O17
CAS Number 349545-02-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tsung-Ming Yeh et al. Molecules. Tea Seed Kaempferol Triglycoside Attenuates LPS-Induced Systemic Inflammation and Ameliorates Cognitive Impairments in a Mouse Model

[2] Zhennan Wang et al. Nat Prod Res. Flavonoids and other phenolics from Camellia nitidissima chi flowers

[3] Hyun Jeong An et al. Food Sci Biotechnol. New caryophyllene-type sesquiterpene and flavonol tetraglycoside with sixteen known compounds from sword bean ( Canavalia gladiata)

[4] Xin-Lan Chen et al. Nat Prod Res. Flavonoid glycosides from the nectar of Camellia reticulata Lindl

[5] Gadah Abdulaziz Al-Hamoud et al. Molecules. Four New Flavonoids Isolated from the Aerial Parts of Cadaba rotundifolia Forssk. (Qadab)

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