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3-Nitro-L-tyrosine

Cat. No. M20883
3-Nitro-L-tyrosine Structure
Synonym:

3-NT, N-Tyr, MNT

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Biological Activity

3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT), synthesized from L-tyrosine by peroxynitrite, is a product of nitric oxide and superoxide. 3-Nitro-L-tyrosine inhibits the hemodynamic responses to angiotensin II, possibly through the inhibition of alpha 1-adrenoceptor-mediated events.

Chemical Information
Molecular Weight 226.19
Formula C9H10N2O5
CAS Number 621-44-3
Solubility (25°C) DMSO 2 mg/mL
Water 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sudip Karmakar, et al. Langmuir. A Simplified Approach for the Aqueous Synthesis of Luminescent CdSe/ZnS Core/Shell Quantum Dots and Their Applications in Ultrasensitive Determination of the Biomarker 3-Nitro-l-tyrosine

[2] Balasubramanian Sriram, et al. Inorg Chem. In Situ Synthesis of a Bismuth Vanadate/Molybdenum Disulfide Composite: An Electrochemical Tool for 3-Nitro-l-Tyrosine Analysis

[3] Mariusz G Fleszar, et al. Molecules. Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period

[4] Leila Mahmoudi, et al. Biochemistry. Electrode Potentials of l-Tryptophan, l-Tyrosine, 3-Nitro-l-tyrosine, 2,3-Difluoro-l-tyrosine, and 2,3,5-Trifluoro-l-tyrosine

[5] Siu Pang Ng, et al. Biosens Bioelectron. Label-free detection of 3-nitro-l-tyrosine with nickel-doped graphene localized surface plasmon resonance biosensor

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Keywords: 3-Nitro-L-tyrosine, 3-NT, N-Tyr, MNT supplier, Adrenergic Receptor, inhibitors, activators

 
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