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3-Mercapto-1-propanol

Cat. No. M40883
3-Mercapto-1-propanol Structure
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Biological Activity

3-Mercapto-1-propanol can be used for the preparation of hydrophilic self-assembled monolayers and as a non-marking linker molecule for chemical and enzymatic synthesis of oligosaccharides.

Chemical Information
Molecular Weight 92.16
Formula C3H8OS
CAS Number 19721-22-3
Form Liquid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lingyi Zhao et al. Spectrochim Acta A Mol Biomol Spectrosc. Solid chip-based detection of trace morphine in solutions via portable surface-enhanced Raman spectroscopy

[2] Indrė Aleknavičienė et al. Molecules. The Impact of an Anchoring Layer on the Formation of Tethered Bilayer Lipid Membranes on Silver Substrates

[3] Mohan Vedhanayagam et al. Biomed Mater. Nanorod mediated collagen scaffolds as extra cellular matrix mimics

[4] Nathalie Moreira et al. Food Chem. Relationship between nitrogen content in grapes and volatiles, namely heavy sulphur compounds, in wines

[5] Orawan Thipmanee et al. Biosens Bioelectron. Label-free capacitive DNA sensor using immobilized pyrrolidinyl PNA probe: effect of the length and terminating head group of the blocking thiols

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