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3-Deazaadenosine

Cat. No. M7775

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3-Deazaadenosine Structure
Synonym:

3-DZA

Size Price Availability
1mg USD 200  USD200 3-4 Weeks
5mg USD 500  USD500 3-4 Weeks
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Quality Control & Documentation
Biological Activity

3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

Product Citations
Chemical Information
Molecular Weight 266.25
Formula C11H14N4O4
CAS Number 6736-58-9
Solubility (25°C) Water: 6 mg/mL (with heating to 60 °C)
Storage 2-8°C, dry, protect from light, sealed
References

[1] Naoto Hinotani, et al. Convenient Synthesis of 3-Deazapurine Nucleosides (3-Deazainosine, 3-Deazaadenosine and 3-Deazaguanosine) Using Inosine as a Starting Material

[2] Raphael Bereiter, et al. Impact of 3-deazapurine nucleobases on RNA properties

[3] Woo Seok Yang, et al. 3-Deazaadenosine, an S-adenosylhomocysteine hydrolase inhibitor, attenuates lipopolysaccharide-induced inflammatory responses via inhibition of AP-1 and NF-κB signaling

[4] Noriko Saito-Tarashima, et al. Groove modification of siRNA duplexes to elucidate siRNA-protein interactions using 7-bromo-7-deazaadenosine and 3-bromo-3-deazaadenosine as chemical probes

[5] Alexander C Langheinrich, et al. 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice

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Keywords: 3-Deazaadenosine, 3-DZA supplier, Anti-infection, inhibitors, activators

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