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3-Chloro-L-alanine

Cat. No. M40724
3-Chloro-L-alanine Structure
Synonym:

β-Chloro-L-alanine; L-β-Chloroalanine

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100mg USD 65  USD65 In stock
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Biological Activity

3-Chloro-L-alanine is an inhibitor of kynureninase as well as an inhibitory amino acid analog that inhibits the activity of several enzymes (e.g. threonine deaminase, alanine racemase).

Chemical Information
Molecular Weight 123.54
Formula C3H6ClNO2
CAS Number 2731-73-9
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Koshiki Mino et al. FEBS Lett. A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1

[2] S Orzechowski et al. Acta Biochim Pol. Alanine aminotransferase and glycine aminotransferase from maize (Zea mays L.) leaves

[3] R Contestabile et al. Eur J Biochem. The mechanism of high-yielding chiral syntheses catalysed by wild-type and mutant forms of aspartate aminotransferase

[4] M Miyawaki et al. J Biochem. A critical arginine residue in cytosolic aspartate aminotransferase from pig heart

[5] Y Morino et al. J Biol Chem. Affinity labeling of alanine aminotransferase by 3-chloro-L-alanine

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  Catalog
Abmole Inhibitor Catalog




Keywords: 3-Chloro-L-alanine, β-Chloro-L-alanine; L-β-Chloroalanine supplier, Anti-infection, inhibitors, activators

 
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