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2-Iodoadenosine

Cat. No. M41561
2-Iodoadenosine Structure
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Biological Activity

2-Iodoadenosine is an adenosine analog.

Chemical Information
Molecular Weight 393.14
Formula C10H12IN5O4
CAS Number 35109-88-7
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Erica W van Tilburg et al. Bioorg Med Chem. 2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A2A receptor

[2] N Naber et al. Protein Sci. A novel adenosine triphosphate analog with a heavy atom to target the nucleotide binding site of proteins

[3] B Estupiñán et al. J Biol Chem. Guanosine-inosine-preferring nucleoside N-glycohydrolase from Crithidia fasciculata

[4] A Matsuda et al. Chem Pharm Bull (Tokyo). Palladium-catalyzed cross-coupling of 2-iodoadenosine with terminal alkynes: synthesis and biological activities of 2-alkynyladenosines

[5] A Matsuda et al. J Med Chem. Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects

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Keywords: 2-Iodoadenosine supplier, Nucleoside Antimetabolite/Analog, inhibitors, activators

 
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