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2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. 2-Aminopurine has been used to probe nucleic acid structure and dynamics. 2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes. 2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
| Molecular Weight | 135.13 |
| Formula | C5H5N5 |
| CAS Number | 452-06-2 |
| Solubility (25°C) | formic acid:water (1:1 v/v) (50 mg/ml) with heating |
| Storage | 2-8°C, protect from light, sealed |
[1] Pai Peng, et al. Analyst. DNA nanodevices monitored with fluorogenic looped-out 2-aminopurine
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