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1,3,6-Tri-O-galloyl-beta-D-glucose

Cat. No. M39887
1,3,6-Tri-O-galloyl-beta-D-glucose Structure
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Biological Activity

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloyl-β-D-glucose) is a phenolic compound in Black Walnut Kernels.

Chemical Information
Molecular Weight 636.47
Formula C27H24O18
CAS Number 18483-17-5
Form Solid
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mohamed Haddad et al. Int J Mol Sci. Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 Infectivity

[2] Jing Gong et al. Biomed Chromatogr. Simultaneous determination of gallic acid, methyl gallate, and 1,3,6-tri-O-galloyl-β-d-glucose from Turkish galls in rat plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetics study

[3] Zhi-Gang Yang et al. Molecules. Inhibitory effects of constituents from Euphorbia lunulata on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells

[4] Hari Prasad Devkota et al. Chem Pharm Bull (Tokyo). Diterpene esters and phenolic compounds from Sapium insigne (ROYLE) BENTH. ex HOOK. fil

[5] Roger Gaudreault et al. J Mol Model. Molecular modeling of poly(ethylene oxide) model cofactors; 1,3,6-tri-O-galloyl-beta- d-glucose and corilagin

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