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17α-meT is a Class III AAS with an alkylation at C-17 and with restricted potential of metabolizing substrates for aromatization. In fact, 17α-meT cannot be aromatize to 17β-estradiol, the most potent form of mammalian estrogenic steroids, and the main product of aromatase. A single injection of 17α-meT immediately before the footshock produced significant impairment of inhibitory avoidance learning in males but not females. Our results show that exposure to a single pharmacological dose of 17α-meT during periadolescence exerts sex-specific cognitive effects without affecting anxiety.
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| Animal models | Gonadally-intact male and female Sprague Dawley rats |
| Formulation | 0.9% saline containing 30% cyclodextrin |
| Dosages | 7.5 mg/kg |
| Administration | i.p. |
| Molecular Weight | 302.45 |
| Formula | C20H30O2 |
| CAS Number | 58-18-4 |
| Solubility (25°C) | Soluble in chloroform, ethanol, acetone, methanol |
| Storage | 2-8°C, protect from light, dry, sealed |
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